Biomarkers
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Can you be fat and fit? What a 2025 study actually found

2025 study on fitness, weight, and mortality risk: what it measured, what it found, and what it means for you.

AUTHOR
DM
Dr. Daniel Müller
Medical Advisor
REVIEWED BY
DM
Dr. Daniel Müller
Medical Advisor
UPDATED
June 26, 2026
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Fit people had about the same risk of dying early whether they were lean, overweight or obese, across long-term studies of many thousands of adults.

What you need to know

A 2025 review in the British Journal of Sports Medicine found that people who were fit but overweight or obese did not have a clearly higher risk of dying early than people who were lean and fit. Fitness appeared to absorb much of the risk usually blamed on the scale. The protective signal came from cardiorespiratory fitness, the kind measured by a proper exercise test, not from being loosely active.

But it is not a reason to ignore weight. At every weight, people with lower fitness carried two to three times the risk. The dividing line in the data was fitness, not body size.

The takeaway is not really about weight. It is that one trainable number, your fitness, that tracks how long you are likely to live more closely than the scale does.

What the study found

Researchers writing in the British Journal of Sports Medicine in 2025 pooled prospective studies that measured cardiorespiratory fitness with an exercise test and measured body mass index directly, then compared each group against people who were both normal weight and fit.

Compared with that lean and fit group:

  • Fit, but heavier people were not at a meaningfully higher risk. Overweight-fit came out at 0.96 and obese-fit at 1.11 for all-cause mortality, neither a real increase.
  • Unfit people carried two to three times the risk at every weight, about 1.9 times for normal weight, 1.8 times for overweight, and 2.0 times for obese.
  • For heart-related death, the gap was wider still, reaching around 3.3 times in the obese-unfit group.

The authors' conclusion was measured. Fitness is a strong predictor of mortality and softens the risk linked to extra weight. It does not cancel weight out.

What the headlines got wrong

This was an association, not cause and effect. It shows that fitter people tend to live longer. It cannot show that fitness alone is what made the difference.

A few reasons to keep it in perspective:

  • Fitter people may carry other healthy habits that the studies did not fully capture.
  • Fit here meant measured aerobic capacity, not general busyness or being on your feet all day.
  • The fit-and-heavier estimates rested on smaller numbers, so they are less precise. Not statistically different is not the same as identical.
  • Mortality is not the only outcome that matters. Extra weight still links to joint load, sleep apnoea and metabolic disease.

The protective signal is fitness. Not the number on the scale, and not a licence to ignore it.

Why one should pay attention to fitness

Cardiorespiratory fitness, your VO2 max, keeps turning up as one of the strongest predictors of how long people live, often holding its own against the classic risk factors. The American Heart Association has argued it should be treated as a clinical vital sign, measured the way blood pressure is.

What makes it worth your attention is that it moves:

  • It responds to training within months.
  • It is largely within your control.
  • It compounds, the same capacity shows up as more energy, faster recovery and steadier markers underneath.

That is what makes fitness one of the most useful numbers in longevity. It turns being healthier into something you can measure and, over time, move. For the full picture, see our complete guide to VO2 max and longevity.

What this means for you

If you take one thing from the study, take this:

  • Build your aerobic base before you fixate on the scale. Most weeks, the fitness work moves your risk further than the diet maths.
  • Weight still counts, it is just not the whole story. Fit and a healthy weight is the strongest place to be.
  • Slim but unfit is the quiet risk. A normal weight can hide low fitness, and the data suggests that it is the riskier place to be.

You can be heavier and fit and outlive someone who is lean and unfit. What you cannot do is skip the fitness.

Knowing where you stand is its own question. Fitness itself is measured as VO2 max, from a lab test or a good wearable estimate, and a blood panel will not give you that number. What a panel shows is where your fitness is landing inside your body, the difference between being in range and being optimal:

  • A routine blood test is designed to catch illness, reading your results against ranges set wide enough to flag disease across a whole population.
  • That is a different job from showing how well your training is actually working.

The cardiovascular and metabolic markers that aerobic fitness affects, things like inflammation and blood lipids, live right in that gap. Fitness is the lever. Your markers tell you whether it is working.

See what a full Axo panel measures

A few questions worth answering

  1. Can you be fat and fit? 

By this study's evidence, largely yes, for the specific question of mortality risk. Fit people who were overweight or obese did not show a clearly higher risk of dying early than people who were lean and fit. It does not mean weight is irrelevant to overall health, only that fitness carries much of the protection.

  1. Is it better to be fit or thin? 

If you had to choose, which data points to fit? Unfit people carried two to three times the mortality risk at every body size, including a normal one. A healthy weight plus good fitness is the strongest combination, but fitness appears to be the more powerful single factor.

  1. How do I know if I am fit? 

The studies defined fitness as cardiorespiratory fitness, or VO2 max, from an exercise test. You can get this from a lab test or estimate it from a quality wearable. As a rough everyday sign, holding a brisk pace or climbing stairs without your heart rate spiking is a reasonable proxy.

  1. Does losing weight still matter? 

Yes. Excess weight links to plenty of conditions beyond early death, from joint strain to metabolic disease. The study's point is not that weight stops mattering; it is that fitness deserves at least as much of your attention, and probably first.

  1. What is VO2 max? 

VO2 max is the maximum amount of oxygen your body can use during hard exercise. It is the standard measure of cardiorespiratory fitness, the thing this study linked to mortality, and it rises with consistent aerobic training.

Sources

Weeldreyer NR, De Guzman JC, Paterson C, Allen JD, Gaesser GA, Angadi SS. Cardiorespiratory fitness, body mass index and mortality: a systematic review and meta-analysis. British Journal of Sports Medicine. 2025;59(5):339–346. DOI: 10.1136/bjsports-2024-108748. Open access. https://pmc.ncbi.nlm.nih.gov/articles/PMC11874340/

Ross R, Blair SN, Arena R, et al. Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign. Circulation. 2016;134(24):e653–e699. https://www.ahajournals.org/doi/10.1161/CIR.0000000000000461

Barry VW, Caputo JL, Kang M. The Joint Association of Fitness and Fatness on Cardiovascular Disease Mortality: A Meta-Analysis. Progress in Cardiovascular Diseases. 2018. https://pubmed.ncbi.nlm.nih.gov/29981352/