Decoding Your Alkaline Phosphatase Blood Test Results

An abnormal lab result can feel like a flashing red light, but it’s really more of a check engine light. It’s not a diagnosis—it’s a signal to look closer. The alkaline phosphatase blood test is one of those key signals, measuring an enzyme made in your liver and bones. When your level is high or low, it simply tells you and your doctor where to focus. This guide is here to help you understand that signal. We’ll cover what causes ALP levels to change and what your next steps are, showing you why this number is a valuable starting point.

Key Takeaways

• View your ALP level as a starting point: This simple blood test measures a key enzyme from your liver and bones, offering an initial clue about your internal health. An abnormal result isn't a diagnosis; it's a signal that prompts a closer look.
• Understand what influences your number: Your ALP result isn't static, as factors like your age, diet, medications, and pregnancy can all affect it. Always discuss your results with your doctor, who can interpret them in the context of your unique health profile.
• Prioritize tracking over single tests: A one-time result is just a snapshot, but monitoring your ALP levels over time reveals meaningful trends. This long-term view is essential for a proactive health strategy, helping you make informed decisions based on patterns, not isolated numbers.

What Is an Alkaline Phosphatase (ALP) Blood Test?

If you’ve ever looked at a lab report, you’ve likely seen a long list of acronyms. ALP is one of them, and it’s a really useful piece of your health puzzle. An Alkaline Phosphatase (ALP) test is a simple blood test that’s often part of a routine check-up or a comprehensive metabolic panel. Think of it as one of many data points, like the ones we track at Axo Longevity, that helps create a clear picture of your overall health. It doesn't tell the whole story on its own, but it's a fantastic starting point for understanding what’s happening inside your body, particularly with your liver and bones.

What Does an ALP Test Actually Measure?

So, what exactly is this test looking for? An ALP test measures the level of a specific enzyme in your blood called alkaline phosphatase. Enzymes are basically tiny protein helpers that speed up essential chemical reactions throughout your body, keeping everything running smoothly. When your doctor orders this test, they're checking the concentration of this enzyme in your bloodstream. The result is a number that tells us if the amount of ALP is within a typical range. It’s a straightforward measurement that provides a valuable clue about your internal health, which we can then investigate further.

Where Does Your Body Make ALP?

One of the reasons the ALP test is so useful is that this enzyme is produced in several different places. While it’s found all over your body, the main production sites are your liver and your bones. Smaller amounts are also made in your kidneys, intestines, and even the placenta during pregnancy. Because alkaline phosphatase comes from multiple sources, an unusual level can point to different potential issues. This is why your doctor will look at your ALP result alongside other tests to figure out where the signal is coming from. Is it a sign of something happening in your liver, or is it related to your bone health? This context is key.

Why You Might Need an ALP Blood Test

An ALP test is often part of a routine blood panel, but your doctor might also order one specifically if they want a closer look at your liver or bone health. It’s a versatile marker that helps connect certain symptoms to potential underlying issues. Think of it as an initial flag that tells your health team where to focus their attention next. If you’re experiencing certain symptoms or have risk factors for liver or bone conditions, this test provides a crucial piece of the puzzle for a preventive health approach.

Symptoms That May Prompt an ALP Test

Your doctor might recommend an ALP test if you're dealing with symptoms that hint at a liver or bone issue. For your liver, this could mean persistent fatigue, nausea, pain in the upper right part of your belly, or jaundice (a yellowing of your skin or eyes). On the bone health side, symptoms like ongoing bone pain, breaking bones more easily than you'd expect, or noticing changes in the shape of your bones could also prompt the test. It’s one of the first steps in figuring out what’s causing your discomfort and getting you on the right path to feeling better.

Liver-Related Symptoms

Let's focus on the liver first. Your doctor may want to check your ALP levels if you're feeling constantly drained, nauseous, or have a persistent ache in the upper right side of your abdomen. Another classic sign is jaundice, which causes a yellow tint in your skin and the whites of your eyes when the liver can't properly process a substance called bilirubin. Since your liver is a primary source of ALP, an unusual result on this test is a strong clue that helps your doctor investigate these symptoms further. It’s a key piece of data for understanding your liver's health and function.

Bone-Related Symptoms

Now for the bone connection. An ALP test is also valuable if you're experiencing symptoms related to your skeletal system. This could include ongoing bone pain without a clear cause, breaking bones more easily than you might expect, or even noticing changes in the shape of your bones over time. Because ALP plays a vital role in bone formation and repair, elevated levels can signal that your bone cells are working overtime. This increased activity might be from a healing fracture or another underlying issue that affects bone metabolism, prompting a more detailed look at your bone health.

Assessing Your Liver Health

One of the primary reasons for an ALP test is to check on your liver. Elevated ALP levels can be a sign that something is interfering with liver function. The test helps your doctor investigate conditions like blocked bile ducts, hepatitis (liver inflammation), or cirrhosis (liver scarring). It's a key part of a comprehensive liver panel that gives a clearer picture of your liver's health. By tracking this biomarker over time, you and your doctor can spot changes early and take proactive steps to protect this vital organ.

Investigating Your Bone Health

If your liver function tests come back normal but your ALP is still high, the focus often shifts to your bones. High ALP can point to conditions that affect bone growth and breakdown. For example, it can be an indicator of Paget's disease of bone, a condition that causes bones to become enlarged and weak. It may also be used to investigate other issues like a significant vitamin D deficiency (osteomalacia) or, in rare cases, bone cancer. This makes the ALP test a valuable tool for understanding your skeletal health and ensuring your bones stay strong.

Monitoring Existing Conditions and Treatments

If you've already been diagnosed with a liver or bone condition, the ALP test becomes a regular part of your health toolkit. It’s not just about finding a problem; it’s about managing it effectively. By regularly checking your ALP levels, your doctor can see if your treatment plan is working as it should. According to the Cleveland Clinic, this ongoing monitoring helps determine if your condition is improving or needs a different approach. This is where a long-term perspective becomes crucial. A single test is a snapshot, but tracking your ALP over time reveals meaningful trends. This allows you and your health team to make informed decisions based on patterns, not isolated numbers, which is a core part of a proactive strategy to manage your health effectively.

What's a Normal ALP Level?

When you get your lab results back, one of the first things you’ll look for is the "normal" range. For alkaline phosphatase, this can be a little tricky because there isn’t one universal standard. While many labs consider a normal range to be between 44 and 147 international units per liter (IU/L), others might use a range of 30 to 120 IU/L.

So, what gives? Different laboratories use slightly different equipment and methods, which is why their reference ranges can vary. The most important thing to do is compare your number to the specific range provided on your lab report. That range is your true north.

Think of your ALP level not as a fixed number but as a dynamic data point that reflects what’s happening in your body at a specific moment. It’s influenced by a whole host of factors, from your age and sex to whether you had a fatty meal before your blood draw. Understanding these variables is the first step in making sense of your results and having a productive conversation with your doctor. It’s all part of building a clearer picture of your unique health profile. For anyone serious about preventive health, knowing what influences your biomarkers is just as important as knowing the numbers themselves.

How Age, Sex, and Pregnancy Affect ALP Levels

Your personal ALP number is shaped by your life stage. Age and sex can significantly influence ALP levels, so what’s normal for a teenager isn’t the same as what’s normal for a 40-year-old. Children and adolescents naturally have much higher ALP levels because their bones are still growing and developing. Levels can also creep up in older adults.

Sex plays a role, too. Men tend to have slightly higher ALP levels than women, especially between the ages of 15 and 50.

For women, pregnancy is a major factor. During the second and third trimesters, it’s completely normal for ALP levels to rise, sometimes to two or three times the usual amount. This happens because the placenta produces its own ALP, contributing to the total in your bloodstream.

What Else Can Influence Your ALP Levels?

Beyond the basics of age, sex, and pregnancy, several other factors can affect ALP levels. Certain medications can shift your numbers; for example, some birth control pills may lower your ALP, while other drugs can cause it to increase. It’s always a good idea to make sure your doctor has a complete list of all medications and supplements you’re taking.

Your diet can also have a short-term effect. Eating a fatty meal within a few hours of your blood test can cause a temporary spike in your ALP. This is why some doctors may ask you to fast before the test.

Finally, if you’re healing from a broken bone, your body will be working overtime to repair it, a process that can also lead to elevated ALP.

What Do High or Low ALP Levels Mean?

Getting your lab results back can feel like trying to read a different language. An "abnormal" flag next to your ALP level doesn't automatically mean something is wrong, but it is a signal from your body that deserves attention. Your result is a single data point in your larger health story. Let's look at what high and low ALP levels might indicate.

How High ALP Relates to Your Liver

If your ALP levels are high, one of the first places your doctor will look is your liver. Extremely high levels can be a strong signal of liver damage or disease, like hepatitis. It can also point to a blockage in your bile ducts, the small tubes that carry bile from your liver. When a bile duct is completely blocked, it can cause ALP levels to spike dramatically, which requires prompt medical attention. Think of it as a traffic jam in your liver’s transport system; the backup causes pressure and signals that something is wrong.

What High ALP Means for Your Bones

Your liver isn't the only potential source of high ALP. Your bones produce it, too. Elevated levels might point to a bone disorder like Paget's disease, which can cause bones to become enlarged and weak. It could also be a sign of a healing fracture, as your body is actively working to rebuild bone tissue. Even issues with your thyroid or parathyroid glands can influence ALP. It’s important to note that slightly high levels might not indicate a serious problem, but it’s a valuable clue that helps your health team understand what’s happening inside your body.

Specific Bone Conditions Linked to High ALP

If your liver tests are normal but your ALP is still high, the investigation naturally turns to your bones. Elevated ALP can be a sign that your body is in a state of high bone turnover, meaning bone tissue is being broken down and rebuilt at an accelerated rate. This can point to specific bone disorders like Paget's disease of bone, a condition where the normal process of bone renewal is disrupted, leading to bones that are enlarged and structurally weak. It could also simply mean you’re healing from a fracture, as your body ramps up ALP production to actively repair the bone. This is why context is everything; a high ALP level in someone recovering from a ski injury means something very different than in someone with unexplained bone pain.

Other Medical Conditions That Can Cause High ALP

While the liver and bones are the main suspects, they aren't the only ones. High ALP can sometimes be a signal from other parts of your body. For instance, certain heart conditions, like congestive heart failure, can lead to elevated levels. Other possibilities include serious infections, mononucleosis ("mono"), or even kidney issues. This wide range of potential causes underscores why a single biomarker is never the full story. It’s a clue that needs to be interpreted within a broader context of your overall health, other lab results, and any symptoms you might be experiencing. This is where a comprehensive approach to health, looking at a wide array of biomarkers, becomes so valuable for getting a clear and complete picture.

The Role of ALP in Cancer

It's important to discuss the connection between ALP and cancer, not to cause alarm, but to be fully informed. In some cases, high ALP levels can be associated with certain cancers. This is particularly true for cancers that have spread (metastasized) to the liver or bones, such as prostate, lung, or stomach cancer. When cancer cells invade these tissues, they can disrupt normal function and cause an increase in ALP production. It's crucial to remember that high ALP is not a direct diagnosis of cancer. Instead, it serves as a potential red flag that, when combined with other diagnostic tools and imaging, helps doctors build a complete picture and determine the next steps in an investigation.

ALP as a Cancer Marker

Going a step further, ALP can sometimes serve as a prognostic marker, offering insights into a cancer's potential behavior. The role it plays can be complex. For some cancers, like prostate, liver, and pancreatic cancer, a high ALP level can be associated with a more challenging prognosis. However, the opposite can be true for other types. For example, some research suggests that low ALP levels might indicate a worse outlook for patients with breast or colorectal cancers. This highlights the nuanced role of this enzyme and reinforces that interpreting these markers requires expertise. It’s not about a single "good" or "bad" number, but about understanding what that number means in the context of a specific condition.

How ALP Levels Can Indicate Prognosis

Beyond diagnosis, tracking ALP levels over time can be incredibly useful for monitoring how well a cancer treatment is working. For certain cancers, if a patient is undergoing chemotherapy or radiation, doctors can watch their ALP levels to gauge the treatment's effectiveness. A significant drop in previously elevated ALP levels can be a positive sign, suggesting that the treatment is successfully reducing the tumor's activity. This is a perfect example of why tracking biomarkers over time is so powerful. It moves beyond a single snapshot, allowing you and your health team to see trends and make informed decisions based on how your body is responding.

What Do Low ALP Levels Mean?

While high ALP gets more attention, low levels can also provide important health insights. A lower-than-normal ALP result is less common but can be a sign of a few different things. Often, it’s linked to nutritional issues. For example, a deficiency in zinc or magnesium can lead to low ALP. It may also point to an underactive thyroid (hypothyroidism). Because it’s less frequent, a low reading is a key piece of data that can help uncover underlying conditions that might otherwise be missed, highlighting the importance of comprehensive biomarker testing.

Nutritional Factors and Low ALP

If your ALP is low, one of the first things to consider is your nutritional status. Your body needs specific raw materials to produce enzymes, and a shortfall can impact their levels. Low ALP is often connected to deficiencies in key minerals, particularly zinc and magnesium. These minerals act as cofactors, which are essentially "helper molecules" that enzymes like alkaline phosphatase need to function correctly. Without enough of them, your body can't produce or activate ALP effectively. This is a perfect example of how a simple blood test can provide a window into your nutritional health, offering clues that might lead to simple but effective dietary adjustments or targeted supplementation under your doctor's guidance.

Genetic and Other Conditions Causing Low ALP

Beyond nutrition, a low ALP reading can also signal other underlying health conditions. One possibility is an underactive thyroid, or hypothyroidism, a condition where your thyroid gland doesn't produce enough crucial hormones, slowing down many of your body's functions, including enzyme production. In rarer cases, very low ALP can be a marker for a genetic condition called hypophosphatasia, which affects bone and tooth development. Because low ALP is less common than high ALP, it serves as a particularly important flag. It’s a key piece of data that prompts a deeper investigation, helping to uncover issues that might otherwise go unnoticed and underscoring the value of a comprehensive health picture.

The Link Between Low ALP and Genetic Conditions

In some cases, consistently low ALP levels can be an indicator of a rare genetic condition. One such condition is hypophosphatasia, a disorder that affects the development of your bones and teeth. This is a perfect example of why tracking your biomarkers over time is so valuable. A single low reading might not be significant, but a consistent pattern provides your health team with the information they need to investigate further. It allows for a proactive approach, helping you identify potential genetic predispositions and manage your health with precision.

Your ALP Results Are Abnormal. Now What?

Seeing an "abnormal" flag next to any test result can be unsettling, but it's important to see it for what it is: a starting point, not a final diagnosis. When your alkaline phosphatase (ALP) levels are outside the normal range, it’s simply a signal that something deserves a closer look. Your body produces ALP in several places, primarily your liver and bones, so the next step is to figure out which area is sending the signal. This single number is just one piece of your health puzzle.

Think of an abnormal ALP result as a check engine light in your car. It tells you that a mechanic (your doctor) needs to run further diagnostics to identify the specific issue. Your doctor will consider your ALP level alongside your symptoms, medical history, and other biomarker results to decide on the next steps. Often, this involves more targeted testing to pinpoint the source of the elevated or low ALP and understand the root cause. At Axo Longevity, we use your comprehensive biomarker profile to interpret these signals in the context of your complete health picture, helping you move from uncertainty to clear, actionable insights.

Next Steps if Your Liver Is the Concern

If your doctor suspects your high ALP is related to your liver, they won't rely on this single number for a diagnosis. Instead, they’ll likely order a panel of other liver function tests. These tests measure different enzymes and proteins, and together, they provide a much more detailed view of your liver's health and function. Very high ALP levels can sometimes point to conditions like hepatitis or a blockage in the bile ducts, which are the tubes that carry bile from your liver. By looking at the complete picture, your health team can get to the bottom of what’s causing the elevation and create a plan to address it.

Next Steps if Your Bones Are the Concern

What if your liver tests come back normal, but your ALP is still high? In this case, the focus shifts to your bones. Elevated ALP can be a sign of increased bone cell activity. This isn't always a cause for concern; for example, it can happen when a fracture is healing. However, it can also indicate a bone disorder, like Paget's disease of bone, or issues with your parathyroid glands, which help regulate calcium in your body. Your doctor might recommend imaging tests or further blood work to investigate your bone health more closely and determine the reason for the high ALP.

Why One Test Result Isn't a Final Diagnosis

It’s completely normal to feel worried about an abnormal test result, but please know that it doesn't automatically mean you have a serious medical condition. Many factors can temporarily affect your ALP levels, including certain medications, your diet, and even your age. For women, pregnancy is a common cause of temporarily elevated ALP. An abnormal result is simply a prompt for a deeper conversation with your doctor. They may suggest an ALP isoenzyme test, which can distinguish between ALP from the liver and ALP from the bones. This provides crucial clarity and helps guide the next steps in your health plan.

Putting Your Results in Context

When you receive your alkaline phosphatase (ALP) test results, it’s essential to see them as one part of a much larger picture. An abnormal reading isn't a diagnosis; it's a signal to look closer. This enzyme is produced primarily in your liver and bones, and its levels can change for many reasons, including your age, diet, medications, and even pregnancy. For instance, kids and teenagers typically have higher ALP levels due to bone growth, while elevated levels are also common during the later stages of pregnancy. Your doctor will consider your results in the context of your overall health, looking at your symptoms and medical history to figure out the next steps. This comprehensive view is what turns a single number into a meaningful health insight.

How to Prepare for Your ALP Blood Test

Getting a blood test can feel a bit out of your hands, but preparing for an ALP test is one area where you have some control. Taking a few simple steps beforehand helps ensure your results are as accurate as possible, giving you and your doctor a clear picture of what’s happening inside your body. Think of it as setting the stage for a clean, reliable reading. At Axo Longevity, we believe that precise data is the foundation of any effective health strategy, and that starts with proper preparation for every one of the biomarkers we test. Here’s what you need to know to get ready for your ALP test.

What to Eat (and What to Skip)

Your doctor will provide specific instructions, but you may be asked to fast for several hours before your test. This usually means no food or drink, except for water. This is often required because other tests are being run from the same blood sample, and food can affect those results. Even on its own, a particularly fatty meal can temporarily increase your ALP levels, so fasting helps establish a true baseline reading. Following these instructions carefully is the best way to make sure your results reflect your body's typical state, not just what you had for breakfast.

Should You Pause Meds, Supplements, or Alcohol?

It’s crucial to give your doctor a complete list of all medications and supplements you’re taking, as some can influence your ALP results. However, never stop taking a prescribed medication unless your doctor explicitly tells you to. It’s also a good idea to avoid drinking alcohol for at least 24 hours before your test, as it can cause a temporary spike in ALP levels. Being transparent about what you consume allows your doctor to interpret your alkaline phosphatase test results with the right context, preventing any unnecessary concern or confusion.

Should You Adjust Your Exercise Routine?

This is a great question, and the answer really comes down to timing. Intense physical activity, like a tough workout or a long run, can cause a temporary increase in your ALP levels. In fact, studies show that strenuous exercise can significantly raise liver enzymes for several days. For this reason, your healthcare team might ask you to skip the gym for a day or two before your blood draw. This isn’t a sign that exercise is harmful; it’s simply a way to get an accurate baseline reading that isn’t influenced by a recent workout. The long-term view is completely different. Consistent, moderate exercise is fantastic for your health. Research suggests that regular aerobic training can actually improve liver function and support the very systems that keep your ALP levels in a healthy range. It’s all about understanding the context behind your numbers—knowing when to pause for an accurate test and when to push forward for long-term health.

What to Ask Your Doctor Before the Test

Open communication is key. Before your blood draw, have a conversation with your doctor about your current health and lifestyle. Be sure to mention if you are pregnant, as pregnancy naturally raises ALP levels. The same goes for any over-the-counter drugs or herbal supplements you take regularly. This information isn’t just background noise; it’s essential data that helps create a complete picture of your health. This collaborative approach is central to how we work at Axo Longevity, ensuring every piece of information is used to build your personalized health plan.

What to Expect During Your Blood Draw

If you’ve never had an ALP test before, it’s completely normal to wonder what the process feels like. The good news is that it’s a very quick and routine procedure. Knowing exactly what will happen from the moment you sit down for the draw to the moment you get your results can help take any anxiety out of the equation. Let’s walk through it step by step so you feel prepared and confident.

During the Test and What Comes After

Getting your blood drawn for an ALP test is simple and fast. A healthcare professional will take a small blood sample from a vein in your arm, a procedure that usually takes only a few minutes. You’ll likely feel a small pinch when the needle goes in, but any discomfort is over quickly. Afterward, you might notice a little soreness or a small bruise at the site, which is completely normal and should fade within a day or two. Most people are in and out and can get right back to their day without any issues.

When Will You Get Your Results?

You won’t have to wait long to see your numbers. Typically, you can expect your ALP test results within one to two days. However, it’s important to remember that a single test result is just a snapshot in time. At Axo Longevity, we focus on how your biomarkers, including ALP, change over time. Tracking these trends gives us a much clearer and more comprehensive picture of your health. This ongoing assessment is far more valuable than any single data point for understanding your body and optimizing your long-term wellness strategy.

Using Your ALP Results for Better Health

Making alkaline phosphatase (ALP) tracking a regular part of your health plan is a smart, proactive step for staying on top of your long-term wellness. The ALP blood test measures an enzyme found mostly in your liver and bones, and it’s often included in routine physicals to screen for potential issues. By monitoring your levels over time, you and your doctor can spot changes early, which is always the best-case scenario for addressing any health concerns that might come up.

If you're already managing a liver or bone condition, regular ALP testing can be especially insightful. According to the Cleveland Clinic, the test helps your doctor see if your condition is improving or staying the same. Think of it as a progress report for your internal health, giving you a clearer picture of how your body is responding to your lifestyle and treatment plan. This kind of data-driven approach puts you in the driver's seat of your own health journey.

It's also helpful to know that an abnormal result isn't automatically a cause for alarm. As the Mayo Clinic explains, many things can affect your ALP levels, including medications, your diet, and even pregnancy. That’s why a single test result is just one piece of a much larger puzzle. At Axo Longevity, we look at over 100 biomarkers, including ALP, to get a comprehensive view of your health. By tracking these markers consistently, we can identify meaningful patterns and provide personalized guidance, helping you feel confident and proactive about your health.

ALP as Part of a Comprehensive Health Picture

Think of your ALP result as a single coordinate on a map. It tells you where you are, but it doesn't show you the whole landscape. An abnormal number on its own can't diagnose a condition; it’s a prompt to zoom out and look at the surrounding terrain. Your doctor will interpret your ALP level in the context of your full health history, any symptoms you have, and other lab results. This is why a comprehensive approach, like the one we use at Axo Longevity with our 100+ biomarker protocol, is so crucial. By analyzing how different markers interact, we can move beyond a single data point and build a truly personalized and proactive plan for your long-term health and performance.

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Frequently Asked Questions

Is a high ALP level always a sign of a serious problem? Not at all. An elevated ALP level is simply a signal that prompts a closer look, not an automatic diagnosis. Many things can cause a temporary or slight increase, such as healing from a broken bone, pregnancy, or even eating a fatty meal before your blood draw. The key is to view the number in context with your other biomarkers, your personal health history, and any symptoms you might have. It’s a starting point for a conversation with your doctor, not a conclusion.

How often should I get my ALP levels checked? For most healthy adults, an ALP test is included as part of a routine annual physical or comprehensive metabolic panel. If you have a known liver or bone condition, or if you and your doctor are monitoring a previously abnormal result, you may need more frequent testing. A consistent, long-term approach to health involves tracking biomarkers like ALP regularly to establish your personal baseline and spot meaningful trends over time.

Can I lower my high ALP levels through diet or lifestyle changes? This really depends on the underlying cause of the elevation. If your high ALP is related to liver stress, then lifestyle adjustments that support liver health, such as maintaining a healthy weight and limiting alcohol, can certainly be beneficial. However, if the cause is a healing fracture or a bone disorder, different actions would be needed. The most effective strategy is to first work with your doctor to pinpoint the source of the high ALP and then create a targeted plan from there.

My ALP is high, but I feel completely fine. Should I still be concerned? This is a great question and it highlights the value of proactive health monitoring. Many conditions, particularly in their early stages, don't present obvious symptoms. An elevated ALP level in someone who feels perfectly healthy can be an important early indicator that something needs attention. It gives you the opportunity to investigate and address a potential issue long before it becomes a more significant problem, which is the entire goal of a preventive health strategy.

What is an ALP isoenzyme test, and why would I need one? Think of the ALP isoenzyme test as a more specific follow-up investigation. Since your body produces different types of ALP in different places (mainly the liver and bones), a high result on a standard test doesn't tell you where it's coming from. The isoenzyme test separates these different types in your blood. This helps your doctor determine if the elevated level is originating from your liver or your bones, which provides crucial clarity for deciding on the right next steps.